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Other important tissues that steroid hormones move through are the liver and the kidneys. The steroids will then return to the heart and continue circulating. ; the liver and steroid hormone metabolism, british medical bulletin, volume 13, issue 2, 1 may 1957, pages 119–125,. Steroid hormones bound to cognate receptors perform diverse functions in lipid metabolism, modulating hepatic steatosis, as well as inflammation. The liver, on the other hand, is the major site for hormone metabolism. In the liver hormones may either be transformed into more active compounds (e. The liver, as a central metabolic organ, plays a crucial role in steroid hormones homeostasis (9, 10) and in the elimination of toxic. The main site of peripheral steroid inactivation and catabolism is the liver, but some catabolic activity also occurs in the kidneys. Steroid metabolism takes place primarily in the liver where the first step involves a reduction of double bonds and the introduction of an hydroxyl in the a

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